PRL-3 - A phosphatase for metastasis?

被引：25

作者：

Sager, JA

Benvenuti, S

Bardelli, A

机构：

[1] Univ Turin, Sch Med, Inst Canc Res & Treatment, IRCC,Oncogenom Ctr, I-10060 Turin, Italy

[2] Johns Hopkins Univ, Inst Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

来源：

CANCER BIOLOGY & THERAPY | 2004年 / 3卷 / 10期

关键词：

PRL-1; PRL-2; PPL-3; phosphatase; metastasis; transcriptional analysis; gene overexpression; prenylation; signal transduction; endothelium; motility; invasion; adhesion; colon cancer; gastric cancer; breast cancer; therapeutic target;

D O I：

10.4161/cbt.3.10.1115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The PRL-3 phosphatase has joined the cancer arena very recently but is rapidly gaining interest both as a putative prognostic factor and as a therapeutic target for metastatic tumors. In this issue Guo and colleagues provide another key piece of information by showing that the catalytic activity of PRL-3 is required for experimental metastasis formation in mouse models. Here we summarize the current knowledge and discuss what remains to be done before PRL-3 could be considered as a target for diagnostics or therapeutics in the clinical setting of human cancer.

引用

页码：952 / 953

页数：2

共 16 条

[1]

Bardelli A, 2003, CLIN CANCER RES, V9, P5607

[2] Prenylation of oncogenic human PTPCAAX protein tyrosine phosphatases [J].