Single molecule force spectroscopy in biology using the atomic force microscope

被引：302

作者：

Zlatanova, J

Lindsay, SM

Leuba, SH

机构：

[1] Argonne Natl Lab, Biochip Technol Ctr, Argonne, IL 60439 USA

[2] Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA

[3] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2000年 / 74卷 / 1-2期

关键词：

atomic force microscopy; DNA stretching; intermolecular interactions; intramolecular interactions; protein unfolding; single molecule force spectroscopy;

D O I：

10.1016/S0079-6107(00)00014-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of forces in biology has been recognized for quite a while but only in the past decade have we acquired instrumentation and methodology to directly measure interactive forces at the level of single biological macromolecules and/or their complexes. This review focuses on force measurements performed with the atomic force microscope. A general introduction to the principle of action is followed by review of the types of interactions being studied, describing the main results and discussing the biological implications. Published by Elsevier Science Ltd.

引用

页码：37 / 61

页数：25

共 112 条

[1] Detection of antigen-antibody binding events with the atomic force microscope [J].