Three-dimensional cross-linked F-actin networks: Relation between network architecture and mechanical behavior

被引：156

作者：

Huisman, E. M. ^{[1
]}

van Dillen, T. ^{[1
]}

Onck, P. R. ^{[1
]}

Van der Giessen, E. ^{[1
]}

机构：

[1] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands

来源：

PHYSICAL REVIEW LETTERS | 2007年 / 99卷 / 20期

关键词：

D O I：

10.1103/PhysRevLett.99.208103

中图分类号：

O4 [物理学];

学科分类号：

0702 [物理学];

摘要：

Numerical simulations are reported for the response of three-dimensional cross-linked F-actin networks when subjected to large deformations. In addition to the physiological parameters such as actin and cross-linker concentration, the model explicitly accounts for filament properties and network architecture. Complementary to two-dimensional studies, we find that the strain-stiffening characteristics depend on network architecture through the local topology around cross-links.

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