Exercise as Medicine for Mental and Substance Use Disorders: A Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes

被引：274

作者：

Ashdown-Franks, Garcia ^{[1
,2
,3
]}

Firth, Joseph ^{[4
,5
,6
]}

Carney, Rebekah ^{[7
]}

Carvalho, Andre F. ^{[8
,9
]}

Hallgren, Mats ^{[10
]}

Koyanagi, Ai ^{[11
]}

Rosenbaum, Simon ^{[12
,13
]}

Schuch, Felipe B. ^{[14
]}

Smith, Lee ^{[15
]}

Solmi, Marco ^{[16
]}

Vancampfort, Davy ^{[17
,18
]}

Stubbs, Brendon ^{[1
,2
,3
]}

机构：

[1] South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Psychol Med, London, England

[3] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada

[4] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia

[5] Univ Manchester, Div Psychol & Mental Hlth, Manchester, Lancs, England

[6] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[7] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England

[8] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[9] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada

[10] Karolinska Inst, Dept Publ Hlth Sci, Unit Epidemiol Psychiat Condit Subst Use & Social, Stockholm, Sweden

[11] Univ Barcelona, Parc Sanitari St Joan de Deu, Res & Dev Unit, Fundacio St Joan de Deu, Dr Antoni Pujadas 42, Barcelona 08830, Spain

[12] Sch Psychiat UNSW, Sydney, NSW, Australia

[13] Black Dog Inst, Sydney, NSW, Australia

[14] Univ Fed Santa Maria, Dept Methods & Sports Tech, Santa Maria, RS, Brazil

[15] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England

[16] Univ Padua, Neurosci Dept, Padua, Italy

[17] Katholieke Univ Leuven, Dept Rehabil Sci, Louvain, Belgium

[18] UPC KU Leuven, Leuven, Belgium

来源：

SPORTS MEDICINE | 2020年 / 50卷 / 01期

关键词：

MAJOR DEPRESSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER; NEUROTROPHIC FACTOR BDNF; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; ANOREXIA-NERVOSA; AEROBIC EXERCISE; METHODOLOGICAL QUALITY; METABOLIC SYNDROME; DIABETES-MELLITUS;

D O I：

10.1007/s40279-019-01187-6

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Background Exercise may improve neuropsychiatric and cognitive symptoms in people with mental disorders, but the totality of the evidence is unclear. We conducted a meta-review of exercise in (1) serious mental illness (schizophrenia spectrum, bipolar disorder and major depression (MDD)); (2) anxiety and stress disorders; (3) alcohol and substance use disorders; (4) eating disorders (anorexia nervosa bulimia nervosa, binge eating disorders, and (5) other mental disorders (including ADHD, pre/post-natal depression). Methods Systematic searches of major databases from inception until 1/10/2018 were undertaken to identify meta-analyses of randomised controlled trials (RCTs) of exercise in people with clinically diagnosed mental disorders. In the absence of available meta-analyses for a mental disorder, we identified systematic reviews of exercise interventions in people with elevated mental health symptoms that included non-RCTs. Meta-analysis quality was assessed with the AMSTAR/+. Results Overall, we identified 27 systematic reviews (including 16 meta-analyses representing 152 RCTs). Among those with MDD, we found consistent evidence (meta-analyses = 8) that exercise reduced depression in children, adults and older adults. Evidence also indicates that exercise was more effective than control conditions in reducing anxiety symptoms (meta-analyses = 3), and as an adjunctive treatment for reducing positive and negative symptoms of schizophrenia (meta-analyses = 2). Regarding neurocognitive effects, exercise improved global cognition in schizophrenia (meta-analyses = 1), children with ADHD (meta-analyses = 1), but not in MDD (meta-analyses = 1). Among those with elevated symptoms, positive mental health benefits were observed for exercise in people with pre/post-natal depression, anorexia nervosa/ bulimia nervosa, binge eating disorder, post-traumatic stress disorder and alcohol use disorders/substance use disorders. Adverse events were sparsely reported. Conclusion Our panoramic meta-overview suggests that exercise can be an effective adjunctive treatment for improving symptoms across a broad range of mental disorders.

引用

页码：151 / 170

页数：20

共 124 条

[1] Exercise in bipolar patients: A systematic review [J].