Current approaches to the management of highly sensitized kidney transplant patients

被引：19

作者：

Suesal, C. ^{[1
]}

Morath, C.

机构：

[1] Heidelberg Univ, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany

来源：

TISSUE ANTIGENS | 2011年 / 77卷 / 03期

关键词：

desensitization; human leukocyte antigen antibodies; kidney transplantation; presensitization; POSITIVE CROSS-MATCH; INTRAVENOUS IMMUNE GLOBULIN; ACCEPTABLE MISMATCH PROGRAM; ANTIBODY-MEDIATED REJECTION; RENAL-ALLOGRAFT RECIPIENTS; SINGLE ANTIGEN BEADS; HLA CLASS-I; LIVING-DONOR; ALLOANTIBODY PRODUCTION; IMMUNOGLOBULINS IVIG;

D O I：

10.1111/j.1399-0039.2011.01638.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the introduction of sensitive antibody detection techniques, effective antibody elimination devices, therapeutic agents, such as bortezomib and eculizumab, and new concepts, such as Heidelberg algorithm, kidney paired exchange, and acceptable mismatch programs, several effective options are now available for the management of highly sensitized kidney transplant patients. However, as the number of human leukocyte antigen-mismatched transplantations is increasing with each year and as long as the elimination or long-term control of donor-specific antibody-producing clones remains an unresolved issue, sensitization will continue to represent a major problem in kidney transplantation.

引用

页码：177 / 186

页数：10

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