Chlamydia pneumoniae and atherosclerosis:: from Koch's postulates to clinical trials

被引：24

作者：

Liu, C

Waters, DD

机构：

[1] San Francisco Gen Hosp, Div Cardiol, Dept Med, San Francisco, CA 94110 USA

[2] Univ Calif San Francisco, San Francisco Med Ctr, San Francisco, CA 94143 USA

[3] Massachusetts Gen Hosp, Dept Internal Med, Boston, MA 02114 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2005年 / 47卷 / 04期

关键词：

D O I：

10.1016/j.pcad.2005.01.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is increasingly viewed as an inflammatory process. A number of infectious agents have been implicated in the pathogenesis of coronary artery disease. Chlamydia pneumoniae has been the most popular and well-studied of these pathogens. It is difficult to prove a causal relationship which requires the fulfillment of Koch's postulates, first developed in the late 1800s, to establish an infectious agent as the cause of a disease process. This paper reviews the evidence for and against Chlamydia pneumoniae infection as a contributing factor to atherosclerosis disease. It examines seroepidemiologic and histopathologic studies as well as animal models using Koch's postulates and then provides an analysis of current clinical trial data.

引用

页码：230 / 239

页数：10

共 46 条

[1] Meta-analysis of sero-epidemiologic studies of the relation between Chlamydia pneumoniae and atherosclerosis:: Does study design influence results? [J].