Relaxin as an additional protective substance in preserving and reperfusion solution for liver transplantation, shown in a model of isolated perfused rat liver

被引：24

作者：

Boehnert, MU ^{[1
]}

Hilbig, H

Armbruster, FP

机构：

[1] Univ Bern, Dept Visceral & Transplant Surg, Inselspital Bern, CH-3010 Bern, Switzerland

[2] Univ Leipzig, Dept Anat, D-04103 Leipzig, Germany

[3] Immundiagnost, D-64625 Bensheim, Germany

来源：

RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE | 2005年 / 1041卷

关键词：

relaxin; reperfusion injury; liver; transplantation; ischemia;

D O I：

10.1196/annals.1282.065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reperfusion injury is a problem in organ transplantation. Relaxin causes vessel dilation and inhibition of platelet and mast cell activation. The study investigates the protective effect of relaxin on liver tissue against cell damage during organ preservation and reperfusion. Liver transplantation was simulated in a model of isolated perfused rat liver. Relaxin was applicated during reperfusion and/or preservation. To quantify cell damage, we examined the perfusate for malonyldialdehyde (MDA) and myeloperoxidase activity (MPO), and liver tissue underwent immunohistochemical study. Relaxin as an additional substance in preserving/reperfusion solution decreases MPO and MDA levels in the perfusate and immunohistochemical study. Relaxin seems to have a protective effect against cell damage in ischemia and reperfusion injury.

引用

页码：434 / 440

页数：7

共 9 条

[1]

Bani D, 1998, AM J PATHOL, V152, P1367

[2] PRINCIPLES OF SOLID-ORGAN PRESERVATION BY COLD-STORAGE [J].

BELZER, FO ;

SOUTHARD, JH .

TRANSPLANTATION, 1988, 45 (04) :673-676

[3]

ERHARD J, 1994, TRANSPLANT INT, V7, P177, DOI 10.1111/j.1432-2277.1994.tb01287.x

[4] HTK-SOLUTION (BRETSCHNEIDER) FOR HUMAN LIVER-TRANSPLANTATION - 1ST CLINICAL-EXPERIENCES [J].

GUBERNATIS, G ;

PICHLMAYR, R ;

LAMESCH, P ;

GROSSE, H ;

BORNSCHEUER, A ;

MEYER, HJ ;

RINGE, B ;

FARLE, M ;

BRETSCHNEIDER, HJ .

LANGENBECKS ARCHIV FUR CHIRURGIE, 1990, 375 (02) :66-70

[5]

JAMIESON NV, 1989, EUR J GASTROEN HEPAT, V1, P83

[6]

PEGG, 1982, SCIENCE, V231, P234

[7] 6-HOUR PORCINE LIVER-STORAGE WITHOUT FLUSHING OR PERFUSION [J].

PIENAAR, BH ;

STAPLETON, GN ;

BRACHER, M ;

LOTZ, Z ;

INNES, CR ;

FOURIE, J ;

HICKMAN, R .

TRANSPLANTATION, 1991, 52 (01) :38-43

[8]

SINGER D, 1990, THORAC CARDIOV SURG, V38, P205, DOI 10.1055/s-2007-1014020

[9]

STARZL TE, 1963, SURG GYNECOL OBSTET, V117, P659

← 1 →