Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

被引：65

作者：

Chakrabarty, Paramita ^{[1
]}

Ceballos-Diaz, Carolina ^{[1
]}

Lin, Wen-Lang ^{[2
]}

Beccard, Amanda ^{[1
]}

Jansen-West, Karen ^{[2
]}

McFarland, Nikolaus R. ^{[3
]}

Janus, Christopher ^{[1
]}

Dickson, Dennis ^{[2
]}

Das, Pritam ^{[2
]}

Golde, Todd E. ^{[1
]}

机构：

[1] Univ Florida, Dept Neurosci, Ctr Translat Res Neurodegenerat Dis, Gainesville, FL 32610 USA

[2] Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA

[3] Univ Florida, Dept Neurol, Gainesville, FL 32610 USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TRANSGENIC MICE; CALCINOSIS; EXPRESSION;

D O I：

10.1038/nn.2829

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that CNS-directed expression of interferon-gamma (IFN-gamma) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-gamma mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

引用

页码：694 / 696

页数：3

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