Age-related hypermethylation of the hMLH1 promoter in gastric cancers

被引：67

作者：

Nakajima, T

Akiyama, Y

Shiraishi, J

Arai, T

Yanagisawa, Y

Ara, M

Fukuda, Y

Sawabe, M

Saitoh, K

Kamiyama, R

Hirokawa, K

Yuasa, Y

机构：

[1] Tokyo Med & Dent Univ, Dept Mol Oncol, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Fac Med, Sch Allied Hlth Sci, Tokyo 113, Japan

[3] Tokyo Med & Dent Univ, Dept Pathol & Immunol, Tokyo 113, Japan

[4] Tokyo Metropolitan Geriatr Hosp, Dept Pathol, Tokyo, Japan

[5] Tokyo Med & Dent Univ, Dept Hlth Promot, Tokyo, Japan

[6] Int Med Ctr Japan, Dept Pathol, Tokyo, Japan

来源：

INTERNATIONAL JOURNAL OF CANCER | 2001年 / 94卷 / 02期

关键词：

aging; methylation; hMLH1; gastric cancer;

D O I：

10.1002/ijc.1454

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people. (C) 2001 Wiley-Liss, Inc.

引用

页码：208 / 211

页数：4

共 24 条

[1]

Ahuja N, 1998, CANCER RES, V58, P5489

[2]

Ahuja N, 1997, CANCER RES, V57, P3370

[3] GENERAL METHOD FOR ISOLATION OF HIGH MOLECULAR-WEIGHT DNA FROM EUKARYOTES [J].