Synthesis of glycoconjugated poly(amindoamine) dendrimers for targeting human liver cancer cells

被引：33

作者：

Guo, Rui ^{[1
,2
]}

Yao, Ying ^{[3
]}

Cheng, Guangcun ^{[3
]}

Wang, Su He ^{[4
]}

Li, Yong ^{[3
]}

Shen, Mingwu ^{[1
]}

Zhang, Yuehua ^{[4
]}

Baker, James R., Jr. ^{[4
]}

Wang, Jianhua ^{[3
]}

Shi, Xiangyang ^{[1
,2
]}

机构：

[1] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cell Biol, Shanghai 200025, Peoples R China

[4] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA

来源：

RSC ADVANCES | 2012年 / 2卷 / 01期

基金：

中国国家自然科学基金;

关键词：

NANOPARTICLES; DELIVERY; GROWTH;

D O I：

10.1039/c1ra00320h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Amine-terminated generation 5 poly(amidoamine) dendrimers were utilized as a platform to conjugate fluorescein isothiocyanate and lactobionic acid. The conjugated lactobionic acid moieties enabled effective targeting to human liver cancer cells (HepG2) in vitro, which was demonstrated by both flow cytometry and confocal microscopy.

引用

收藏

页码：99 / 102

页数：4

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