Nogo 3′-untranslated region CAA insertion:: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion

Novak et al. [Brain Res. Mol. Brain Res. 107 (2002) 183] reported that a CAA insertion in the 3'-untranslated region of the Nogo gene was associated with schizophrenia. We examined the frequency of this CAA insertion in 57 European American subjects with schizophrenia and 243 controls, and in a smaller group of African American subjects (N = 72; 20 with schizophrenia). We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups. (C) 2003 Elsevier B.V. All rights reserved.