Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS

被引:29
作者
Chim, CS [1 ]
Fung, TK [1 ]
Liang, R [1 ]
机构
[1] Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
关键词
D O I
10.1038/sj.leu.2403133
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:2533 / 2535
页数:3
相关论文
共 8 条
[1]   Methylation of p15 and p16 genes in acute promyelocytic leukemia:: Potential diagnostic and prognostic significance [J].
Chim, CS ;
Liang, R ;
Tam, CYY ;
Kwong, YL .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (07) :2033-2040
[2]  
Fonseca R, 2002, CANCER RES, V62, P715
[3]   Multiple myeloma: Evolving genetic events and host interactions [J].
Kuehl, WM ;
Bergsagel, PL .
NATURE REVIEWS CANCER, 2002, 2 (03) :175-187
[4]   Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis [J].
Kulkarni, MS ;
Daggett, JL ;
Bender, TP ;
Kuehl, WM ;
Bergsagel, PL ;
Williams, ME .
LEUKEMIA, 2002, 16 (01) :127-134
[5]   To cycle or not to cycle: A critical decision in cancer [J].
Malumbres, M ;
Barbacid, M .
NATURE REVIEWS CANCER, 2001, 1 (03) :222-231
[6]  
Mateos M V, 2001, Hematol J, V2, P146, DOI 10.1038/sj.thj.6200084
[7]   Frequent hypermethylation of p16 and p15 genes in multiple myeloma [J].
Ng, MHL ;
Chung, YF ;
Lo, KW ;
Wickham, NWR ;
Lee, JCK ;
Huang, DP .
BLOOD, 1997, 89 (07) :2500-2506
[8]   DELETIONS OF THE CYCLIN-DEPENDENT KINASE-4 INHIBITOR GENE IN MULTIPLE HUMAN CANCERS [J].
NOBORI, T ;
MIURA, K ;
WU, DJ ;
LOIS, A ;
TAKABAYASHI, K ;
CARSON, DA .
NATURE, 1994, 368 (6473) :753-756