Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease

被引：331

作者：

Delgado, M ^{[1
]}

Abad, C ^{[1
]}

Martinez, C ^{[1
]}

Laceta, J ^{[1
]}

Gomariz, RP ^{[1
]}

机构：

[1] Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

来源：

NATURE MEDICINE | 2001年 / 7卷 / 05期

关键词：

D O I：

10.1038/87887

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease of unknown etiology, characterized by chronic inflammation in the joints and subsequent destruction of the cartilage and bone. We describe here a new strategy for the treatment of arthritis: administration of the neuropeptide vasoactive intestinal peptide (VIP). Treatment with VIP significantly reduced incidence and severity of arthritis in an experimental model, completely abrogating joint swelling and destruction of cartilage and bone. The therapeutic effect of VIP was associated with downregulation of both inflammatory and autoimmune components of the disease. Our data indicate VIP as a viable candidate for the development of treatments for RA.

引用

页码：563 / 568

页数：6

共 35 条

[1]

BRENNAN FM, 1989, LANCET, V2, P244

[2]

Butler DM, 1999, EUR J IMMUNOL, V29, P2205, DOI 10.1002/(SICI)1521-4141(199907)29:07<2205::AID-IMMU2205>3.0.CO

[3]

2-Z

[4]

Butler DM, 1997, J IMMUNOL, V159, P2867

[5] VIP and PACAP38 modulate cytokine and nitric oxide production in peritoneal macrophages and macrophage cell lines [J].

Delgado, M ;

Munoz-Elias, EJ ;

Martinez, C ;

Gomariz, RP ;

Ganea, D .

NEUROPEPTIDES: STRUCTURE AND FUNCTION IN BIOLOGY AND BEHAVIOR, 1999, 897 :401-414

[6] Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor α transcriptional activation by regulating nuclear factor-kB and cAMP response element-binding protein/c-Jun [J].

Delgado, M ;

Munoz-Elias, EJ ;

Kan, YQ ;

Gozes, I ;

Fridkin, M ;

Brenneman, DE ;

Gomariz, RP ;

Ganea, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (47) :31427-31436

[7]

Delgado M, 1999, J IMMUNOL, V162, P4685

[8] VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages.: Subsequent effect on IFNγ synthesis by T cells [J].

Delgado, M ;

Munoz-Elias, EJ ;

Gomariz, RP ;

Ganea, D .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 96 (02) :167-181

[9]

Delgado M, 1999, J IMMUNOL, V163, P3629

[10] New therapeutic targets for rheumatoid arthritis [J].

Dinant, HJ ;

Dijkmans, BAC .

PHARMACY WORLD & SCIENCE, 1999, 21 (02) :49-59

← 1 2 3 4 →