Estimating linear regression models in the presence of a censored independent variable

被引:32
作者
Austin, PC
Hoch, JS
机构
[1] Inst Clin Evaluat Sci, Toronto, ON M4N 3M5, Canada
[2] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada
[3] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
基金
英国工程与自然科学研究理事会; 英国惠康基金; 中国国家自然科学基金; 英国医学研究理事会;
关键词
linear regression; ceiling effect; censored independent variable; regression models; censoring;
D O I
10.1002/sim.1601
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The current study examined the impact of a censored independent variable, after adjusting for a second independent variable, when estimating regression coefficients using 'naive' ordinary least squares (OLS), 'partial' OLS and full-likelihood models. We used Monte Carlo simulations to determine the bias associated with all three regression methods. We demonstrated that substantial bias was introduced in the estimation of the regression coefficient associated with the variable subject to a ceiling effect when naive OLS regression was used. Furthermore, minor bias was transmitted to the estimation of the regression coefficient associated with the second independent variable. High correlation between the two independent variables improved estimation of the censored variable's coefficient at the expense of estimation of the other coefficient. The use of 'partial' OLS and maximum-likelihood estimation were shown to result in, at most, negligible bias in estimation. Furthermore, we demonstrated that the full-likelihood method was robust under misspecification of the joint distribution of the independent random variables. Lastly, we provided an empirical example using National Population Health Survey (NPHS) data to demonstrate the practical implications of our main findings and the simple methods available to circumvent the bias identified in the Monte Carlo simulations. Our results suggest that researchers need to be aware of the bias associated with the use of naive ordinary least-squares estimation when estimating regression models in which at least one independent variable is subject to a ceiling effect. Copyright (C) 2004 John Wiley Sons, Ltd.
引用
收藏
页码:411 / 429
页数:19
相关论文
共 29 条
[1]   THE EFFECTS OF MEASUREMENT ERRORS ON RELATIVE RISK REGRESSIONS [J].
ARMSTRONG, BG .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (06) :1176-1184
[2]   Type I error inflation in the presence of a ceiling effect [J].
Austin, PC ;
Brunner, LJ .
AMERICAN STATISTICIAN, 2003, 57 (02) :97-104
[3]   ARE THERE 2 REGRESSIONS [J].
BERKSON, J .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1950, 45 (250) :164-180
[4]  
Blom G., 1958, STAT ESTIMATES TRANS
[5]  
Collett D, 2014, MODELLING SURVIVAL D
[6]  
COX D. R., 2000, Theoretical Statistics
[7]   Effect of dichotomizing a continuous variable on the model structure in multiple linear regression models [J].
Cumsille, F ;
Bangdiwala, SI ;
Sen, PK ;
Kupper, LL .
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS, 2000, 29 (03) :643-654
[8]   A BIBLIOGRAPHY AND COMMENTS ON THE USE OF STATISTICAL-MODELS IN EPIDEMIOLOGY IN THE 1980S [J].
GAIL, MH .
STATISTICS IN MEDICINE, 1991, 10 (12) :1819-1885
[9]  
Greene W.H., 2000, ECONOMETRIC ANAL
[10]   ON THE ASYMPTOTIC BIAS OF THE ORDINARY LEAST-SQUARES ESTIMATOR OF THE TOBIT-MODEL [J].
GREENE, WH .
ECONOMETRICA, 1981, 49 (02) :505-513