MicroRNA control of lymphocyte differentiation and function

被引：68

作者：

Belver, Laura ^{[2
]}

Papavasiliou, F. Nina ^{[1
]}

Ramiro, Almudena R. ^{[2
]}

机构：

[1] Rockefeller Univ, Lab Lymphocyte Biol, New York, NY 10065 USA

[2] Spanish Natl Canc Res Ctr CNIO, DNA Hypermutat & Canc Grp, Madrid 28029, Spain

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 03期

基金：

欧洲研究理事会;

关键词：

INDUCED CYTIDINE DEAMINASE; B-CELL DEVELOPMENT; TRANSGENIC MICE; IMMUNE-SYSTEM; ENZYME DICER; T-CELLS; EXPRESSION; LEUKEMIA; LINEAGE; ABSENCE;

D O I：

10.1016/j.coi.2011.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are a class of endogenous, non-coding regulatory RNAs that control gene regulation by guiding silencing protein complexes to mRNA in a sequence-dependent manner. In this way miRNAs are able to repress gene expression post-transcriptionally by affecting mRNA stability or translation. These ubiquitous molecules play central roles in a wide range of biological processes, including cell proliferation, differentiation and apoptosis. Within the context of the immune system, genetic studies have identified distinct roles for specific miRNAs in gene regulation during development, activation and maturation. Conversely, dysregulation of miRNA expression has been specifically correlated with cancer. This review outlines our current understanding of miRNA function in lymphocytes as it impacts expression of protein-coding genes in the context of proper development, as well as oncogenesis.

引用

页码：368 / 373

页数：6

共 53 条

[1] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[2] Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs [J].

Bartel, DP ;

Chen, CZ .

NATURE REVIEWS GENETICS, 2004, 5 (05) :396-400

[3] Identification of the Human Mature B Cell miRNome [J].

Basso, Katia ;

Sumazin, Pavel ;

Morozov, Pavel ;

Schneider, Christof ;

Maute, Roy L. ;

Kitagawa, Yukiko ;

Mandelbaum, Jonathan ;

Haddad, Joseph, Jr. ;

Chen, Chang-Zheng ;

Califano, Andrea ;

Dalla-Favera, Riccardo .

IMMUNITY, 2009, 30 (05) :744-752

[4] MicroRNAs Prevent the Generation of Autoreactive Antibodies [J].

Belver, Laura ;

de Yebenes, Virginia G. ;

Ramiro, Almudena R. .

IMMUNITY, 2010, 33 (05) :713-722

[5] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[6] A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis [J].

Cheloufi, Sihem ;

Dos Santos, Camila O. ;

Chong, Mark M. W. ;

Hannon, Gregory J. .

NATURE, 2010, 465 (7298) :584-U76

[7] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

[8] Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps [J].

Chi, Sung Wook ;

Zang, Julie B. ;

Mele, Aldo ;

Darnell, Robert B. .

NATURE, 2009, 460 (7254) :479-486

[9]

Chong MMW, 2008, J EXP MED, V205, P2449, DOI [10.1084/jem.20071219090508c, 10.1084/jem.20081219]

[10] A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity [J].

Cifuentes, Daniel ;

Xue, Huiling ;

Taylor, David W. ;

Patnode, Heather ;

Mishima, Yuichiro ;

Cheloufi, Sihem ;

Ma, Enbo ;

Mane, Shrikant ;

Hannon, Gregory J. ;

Lawson, Nathan D. ;

Wolfe, Scot A. ;

Giraldez, Antonio J. .

SCIENCE, 2010, 328 (5986) :1694-1698

← 1 2 3 4 5 6 →