Asymmetric synthesis of dideazafolate antitumor agents via amidomethylation of nonracemic oxazolidinone imidates. Synthesis of LY309887, a cytotoxic dideazafolate analog related to lometrexol

被引：26

作者：

Barnett, CJ ^{[1
]}

Wilson, TM ^{[1
]}

Evans, DA ^{[1
]}

Somers, TC ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(96)02418-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of LY309887, a cytotoxic dideazatetrahydrofolate analog related to lometrexol, has been accomplished via an application of diastereoselective amidomethylation of a chiral titanium (TV) acyloxazolidinone enolate. (C) 1997, Elsevier Science Ltd.

引用

页码：735 / 738

页数：4

共 13 条

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