The neurochip: a new multielectrode device for stimulating and recording from cultured neurons

被引:251
作者
Maher, MP
Pine, J
Wright, J
Tai, YC
机构
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
[2] CALTECH, Div Phys Math & Astron, Pasadena, CA 91125 USA
[3] CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA
关键词
D O I
10.1016/S0165-0270(98)00156-3
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The neurochip is a silicon micromachined device upon which cultured mammalian neurons can be continuously and individually monitored and stimulated. The neurochip is based upon a 4 x 4 array of metal electrodes, each of which has a caged well structure designed to hold a single mature cell body while permitting normal outgrowth of neural processes. We demonstrate that this device is capable of maintaining cell survival, and that the electrodes can both record and stimulate electrical activity in individual cells with no crosstalk between channels. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码:45 / 56
页数:12
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