Serum bile acids in liver cirrhosis promote neutrophil dysfunction

被引：18

作者：

Balazs, Irina ^{[1
,2
]}

Horvath, Angela ^{[1
,2
]}

Leber, Bettina ^{[3
]}

Feldbacher, Nicole ^{[1
,2
]}

Sattler, Wolfgang ^{[4
,5
]}

Rainer, Florian ^{[1
]}

Fauler, Guenter ^{[6
]}

Vermeren, Sonja ^{[7
]}

Stadlbauer, Vanessa ^{[1
,2
]}

机构：

[1] Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria

[2] Ctr Biomarker Res Med CBmed, Graz, Austria

[3] Med Univ Graz, Div Transplantat Surg, Dept Surg, Graz, Austria

[4] Med Univ Graz, Div Mol Biol & Biochem, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Graz, Austria

[5] BioTechMed Graz, Ctr Explorat Lipid, Graz, Austria

[6] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria

[7] Univ Edinburgh, Inst Regenerat & Repair, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2022年 / 12卷 / 02期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1002/ctm2.735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

引用

页数：5

共 10 条

[1]

Innate immune cells in cirrhosis [J].

Bernsmeier, Christine ;

van der Merwe, Schalk ;

Perianin, Axel .

JOURNAL OF HEPATOLOGY, 2020, 73 (01) :186-201

[2]

Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants [J].

Chen, X ;

Mellon, RD ;

Yang, L ;

Dong, HF ;

Oppenheim, JJ ;

Howard, OMZ .

BIOCHEMICAL PHARMACOLOGY, 2002, 63 (03) :533-541

[3]

Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors [J].

Chen, X ;

Yang, D ;

Shen, W ;

Dong, HF ;

Wang, JM ;

Oppenheim, JJ ;

Howard, OMZ .

INFLAMMATION RESEARCH, 2000, 49 (12) :744-755

[4]

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages [J].

Haselow, Katrin ;

Bode, Johannes G. ;

Wammers, Marianne ;

Ehlting, Christian ;

Keitel, Verena ;

Kleinebrecht, Laura ;

Schupp, Anna-Kathrin ;

Haeussinger, Dieter ;

Graf, Dirk .

JOURNAL OF LEUKOCYTE BIOLOGY, 2013, 94 (06) :1253-1264

[5]

A G protein-coupled receptor responsive to bile acids [J].

Kawamata, Y ;

Fujii, R ;

Hosoya, M ;

Harada, M ;

Yoshida, H ;

Miwa, M ;

Fukusumi, S ;

Habata, Y ;

Itoh, T ;

Shintani, Y ;

Hinuma, S ;

Fujisawa, Y ;

Fujino, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :9435-9440

[6]

Role of bile acids in the diagnosis and progression of liver cirrhosis: A prospective observational study [J].

Liu, Ning ;

Feng, Jiao ;

Lv, Yang ;

Liu, Qing ;

Deng, Jingfan ;

Xia, Yujing ;

Guo, Chuanyong ;

Zhou, Yingqun .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 18 (05) :4058-4066

[7]

Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor [J].

Pols, Thijs W. H. ;

Puchner, Teresa ;

Korkmaz, H. Inci ;

Vos, Mariska ;

Soeters, Maarten R. ;

de Vries, Carlie J. M. .

PLOS ONE, 2017, 12 (05)

[8]

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro [J].

Reich, Maria ;

Deutschmann, Kathleen ;

Sommerfeld, Annika ;

Klindt, Caroline ;

Kluge, Stefanie ;

Kubitz, Ralf ;

Ullmer, Christoph ;

Knoefel, Wolfram T. ;

Herebian, Diran ;

Mayatepek, Ertan ;

Haeussinger, Dieter ;

Keitel, Verena .

GUT, 2016, 65 (03) :487-501

[9]

Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis [J].

Rolas, Loic ;

Makhezer, Nesrine ;

Hadjoudj, Soumeya ;

El-Benna, Jamel ;

Djerdjouri, Bahia ;

Elkrief, Laure ;

Moreau, Richard ;

Perianin, Axel .

HEPATOLOGY, 2013, 57 (03) :1163-1171

[10]

The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90-day and 1-year mortality [J].

Taylor, N. J. ;

Vijay, G. K. Manakkat ;

Abeles, R. D. ;

Auzinger, G. ;

Bernal, W. ;

Ma, Y. ;

Wendon, J. A. ;

Shawcross, D. L. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2014, 40 (06) :705-715

← 1 →