Multimodal characterisation of cortical areas by multivariate analyses of receptor binding and connectivity data

被引:38
作者
Kötter, R
Stephan, KE
Palomero-Gallagher, N
Geyer, S
Schleicher, A
Zilles, K
机构
[1] Univ Dusseldorf, C&O Vogt Inst Hirnforsch, D-40225 Dusseldorf, Germany
[2] Univ Dusseldorf, Inst Morphol Endocrinol & Histochem, D-40225 Dusseldorf, Germany
[3] Forschungszentrum Julich, Inst Med, D-52425 Julich, Germany
[4] Univ Dusseldorf, Inst Neuroanat, D-40225 Dusseldorf, Germany
[5] Newcastle Univ, Dept Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源
ANATOMY AND EMBRYOLOGY | 2001年 / 204卷 / 04期
关键词
multivariate statistics; structure-function relationships; visual cortex; motor cortex; primate;
D O I
10.1007/s004290100199
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Cortical areas are regarded as fundamental structural and functional units within the information processing networks of the brain. Their properties have been described extensively by cyto-, myelo- and chemoarchitectonics, cortical and extracortical connectivity patterns, receptive field mapping, activation properties, lesion effects, and other structural and functional characteristics. Systematic integrative approaches aiming at multimodal characterisations of cortical areas or at the delineation of global features of the cortical network, however, are still scarce and usually limited to a single data modality, such as cytoarchitectonical or tract tracing data. Here we describe a methodological framework for the systematic evaluation, comparison and integration of different data modalities from the brain and demonstrate its practical application and significance in the analysis of receptor binding and connectivity data within the motor and visual cortices of macaque monkeys. The framework builds on algorithmic methods to convert data between different cortical parcellation schemes, as well as on statistical techniques for the exploration of multivariate data sets comprising data of different types and scales. Thereby, we establish a relationship between intrinsic area properties as expressed by quantitative receptor binding, and extrinsic inter-area communication, which relies on anatomical connectivity. Our analyses provide preliminary evidence for a good correspondence of these two data types in the motor cortex, and their partial discrepancy in the visual cortex, raising hypotheses about the different organisational aspects highlighted by receptors and connectivity. The methodological framework presented here is flexible enough to accommodate a wide range of further data modalities, and is specific enough to permit novel insights and predictions concerning brain organisation. Thus, this approach promises to be very useful in the endeavour to characterise multimodal structure - function relationships in the brain.
引用
收藏
页码:333 / 350
页数:18
相关论文
共 49 条
[1]   Brodmann's areas 17 and 18 brought into stereotaxic space - Where and how variable? [J].
Amunts, K ;
Malikovic, A ;
Mohlberg, H ;
Schormann, T ;
Zilles, K .
NEUROIMAGE, 2000, 11 (01) :66-84
[2]   CALLOSAL AND PREFRONTAL ASSOCIATIONAL PROJECTING CELL-POPULATIONS IN AREA-7A OF THE MACAQUE MONKEY - A STUDY USING RETROGRADELY TRANSPORTED FLUORESCENT DYES [J].
ANDERSEN, RA ;
ASANUMA, C ;
COWAN, WM .
JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 232 (04) :443-455
[3]  
[Anonymous], 1988, The arboviruses: epidemiology and ecology, vol
[4]  
BACKHAUS K, 1996, MULTIVARIATE ANALYSE
[5]  
Borg I., 1997, MODERN MULTIDIMENSIO
[6]   Organization of primate amygdalo-prefrontal projections [J].
Bozkurt, A ;
Kamper, L ;
Stephan, KE ;
Kötter, R .
NEUROCOMPUTING, 2001, 38 :1135-1140
[7]  
Brodmann K, 1909, VERGLEICHENDE LOKALI
[8]   Analysis of the connectional organization of neural systems associated with the hippocampus in rats [J].
Burns, GAPC ;
Young, MP .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2000, 355 (1393) :55-70
[9]   Subcellular localization of m2 muscarinic receptors in GABAergic interneurons of the olfactory bulb [J].
Crespo, C ;
Blasco-Ibáñez, JM ;
Briñón, JG ;
Alonso, JR ;
Domínguez, MI ;
Martínez-Guijarro, FJ .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (11) :3963-3974
[10]   Distributed Hierarchical Processing in the Primate Cerebral Cortex [J].
Felleman, Daniel J. ;
Van Essen, David C. .
CEREBRAL CORTEX, 1991, 1 (01) :1-47