Multiple functions of microsomal triglyceride transfer protein

被引:204
作者
Hussain, M. Mahmood [1 ]
Rava, Paul [1 ]
Walsh, Meghan [1 ]
Rana, Muhammad [1 ]
Iqbal, Jahangir [1 ]
机构
[1] Suny Downstate Med Ctr, Dept Cell Biol & Pediat, Brooklyn, NY 11203 USA
关键词
CD1; MTP; ApoB; Cholesterol; Triglyceride; Lipoproteins; TRIACYLGLYCEROL TRANSFER PROTEIN; ESTER TRANSFER PROTEIN; APOLIPOPROTEIN-B; HEPATITIS-C; LIPOPROTEIN SECRETION; ACYL-COENZYME; APO-B; ENDOPLASMIC-RETICULUM; DISULFIDE-ISOMERASE; LIPID TRANSPORT;
D O I
10.1186/1743-7075-9-14
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the realization that abetalipoproteinemia patients carry mutations in the MTTP gene resulting in the loss of its lipid transfer activity. Now it is known that it also plays a role in the biosynthesis of CD1, glycolipid presenting molecules, as well as in the regulation of cholesterol ester biosynthesis. In this review, we will provide a historical perspective about the identification, purification and characterization of MTP, describe methods used to measure its lipid transfer activity, and discuss tissue expression and function. Finally, we will review the role MTP plays in the assembly of apoB-lipoprotein, the regulation of cholesterol ester synthesis, biosynthesis of CD1 proteins and propagation of hepatitis C virus. We will also provide a brief overview about the clinical potentials of MTP inhibition.
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页数:16
相关论文
共 149 条
[1]   JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs [J].
Aggarwal D. ;
West K.L. ;
Zern T.L. ;
Shrestha S. ;
Vergara-Jimenez M. ;
Fernandez M.L. .
BMC Cardiovascular Disorders, 5 (1)
[2]   A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein [J].
Athar, H ;
Iqbal, J ;
Jiang, XC ;
Hussain, MM .
JOURNAL OF LIPID RESEARCH, 2004, 45 (04) :764-772
[3]   MECHANISM OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN CATALYZED LIPID TRANSPORT [J].
ATZEL, A ;
WETTERAU, JR .
BIOCHEMISTRY, 1993, 32 (39) :10444-10450
[4]   IDENTIFICATION OF 2 CLASSES OF LIPID MOLECULE-BINDING SITES ON THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN [J].
ATZEL, A ;
WETTERAU, JR .
BIOCHEMISTRY, 1994, 33 (51) :15382-15388
[5]   Apolipophorin II/I, apolipoprotein B, vitellogenin, and microsomal triglyceride transfer protein genes are derived from a common ancestor [J].
Babin, PJ ;
Bogerd, J ;
Kooiman, FP ;
Van Marrewijk, WJA ;
Van der Horst, DJ .
JOURNAL OF MOLECULAR EVOLUTION, 1999, 49 (01) :150-160
[6]   Lysine and arginine residues in the N-terminal 18% of apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein [J].
Bakillah, A ;
Jamil, H ;
Hussain, MM .
BIOCHEMISTRY, 1998, 37 (11) :3727-3734
[7]  
Bakillah A, 2003, FRONT BIOSCI-LANDMRK, V8, pD294
[8]   Binding of microsomal trigrlyceride transfer protein to lipids results in increased affinity for apolipoprotein B - Evidence for stable microsomal MTP-lipid complexes [J].
Bakillah, A ;
Hussain, MM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (33) :31466-31473
[9]   Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist [J].
Bakillah, A ;
Nayak, N ;
Saxena, U ;
Medford, RM ;
Hussain, MM .
BIOCHEMISTRY, 2000, 39 (16) :4892-4899
[10]   STRUCTURE AND FUNCTION OF A LIPOPROTEIN - LIPOVITELLIN [J].
BANASZAK, L ;
SHARROCK, W ;
TIMMINS, P .
ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY, 1991, 20 :221-246