Looking back to the embryo: Defining transcriptional networks in adult myogenesis

被引：281

作者：

Parker, MH

Seale, P

Rudnicki, MA

机构：

[1] Ottawa Hlth Res Inst, Program Mol Med, Ottawa, ON K1H 8L6, Canada

[2] McMaster Univ, Fac Hlth Sci, Hamilton, ON L8S 4K1, Canada

[3] McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrg1109

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Skeletal muscle has an intrinsic capacity for regeneration following injury or exercise. The presence of adult stem cells in various tissues with myogenic potential provides new opportunities for cell-based therapies to treat muscle disease. Recent studies have shown a conserved transcriptional hierarchy that regulates the myogenic differentiation of both embryonic and adult stem cells. Importantly, the molecules and signalling pathways that induce myogenic determination in the embryo might be manipulated or mimicked to direct the differentiation of adult stem cells either in vivo or ex vivo.

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页码：497 / 507

页数：11

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