Comprehensive identification of human bZIP interactions with coiled-coil arrays

被引：378

作者：

Newman, JRS ^{[1
]}

Keating, AE ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

SCIENCE | 2003年 / 300卷 / 5628期

关键词：

D O I：

10.1126/science.1084648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In eukaryotes, the combinatorial association of sequence-specific DNA binding proteins is essential for transcription. We have used protein arrays to test 49(2) pairings of a nearly complete set of coiled-coil strands from human basic-region leucine zipper ( bZIP) transcription factors. We find considerable partnering selectivity despite the bZIPs' homologous sequences. The interaction data are of high quality, as assessed by their reproducibility, reciprocity, and agreement with previous observations. Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response.

引用

页码：2097 / 2101

页数：5

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