Syntheses of two neuromedin U (NMU) analogues and their comparative reducing food intake effect in rats

被引：4

作者：

Abiko, T ^{[1
]}

Takamura, Y ^{[1
]}

机构：

[1] Global Shinwa Pharmaceut Co Ltd, Res Lab, Aoba Ku, Sendai, Miyagi 9810905, Japan

来源：

AMINO ACIDS | 2003年 / 25卷 / 01期

关键词：

neuromedin U; solid-phase method; reducing food intake; neuromedin U analogue; Fmoc strategy; aromatic ring substitution;

D O I：

10.1007/s00726-002-0351-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To examine the roles of aromatic rings Tyr residues at positions 1 and 6 and Phe residues at positions 16, 17 and 19 of rat neuromedin U-23 (NMU-23) (Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2) for reducing food intake activity in male Wistar rats, two NMU-23 analogues, [Phe(4F)(16,17,19)]NMU-23 and [Tyr(Me)(1,6)]NMU-23, were synthesized by Fmoc strategy of manual solid-phase method. The synthetic NMU-23 showed reducing effect on food intake in rats. [Phe(4F)(16,17,19)]NMU-23 exhibited higher reducing food intake effect than that of NMU-23. On the contrary, [Tyr(Me)(1,6)]NMU-23 showed no reducing effect on food intake in rats than that of NMU-23.

引用

页码：107 / 110

页数：4

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