Degeneration and repair in central nervous system disease

被引：96

作者：

Lo, Eng H. ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurol, Neuroprotect Res Lab, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 11期

关键词：

CEREBRAL ENDOTHELIAL-CELLS; AMYLOID-BETA PEPTIDES; ALZHEIMERS-DISEASE; DOPAMINERGIC-NEURONS; NEUROVASCULAR NICHE; PHYSIOLOGICAL ROLES; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; MUTANT HUNTINGTIN; BLOOD-VESSELS;

D O I：

10.1038/nm.2226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Divergent disease triggers in neurodegeneration may induce convergent endogenous pathways in neuronal, glial and vascular elements as the central nervous system (CNS) attempts to compensate, remodel and recover. Dissecting these multicellular mechanisms and the integrative responses in cerebral blood flow and metabolism may allow us to understand the balance between injury and repair, validate new targets and define therapeutic time windows for neurodegeneration.

引用

页码：1205 / 1209

页数：5

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