Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis

被引:53
作者
Imaida, K
Tamano, S
Kato, K
Ikeda, Y
Asamoto, M
Takahashi, S
Nir, Z
Murakoshi, M
Nishino, H
Shirai, T
机构
[1] Nagoya City Univ, Dept Pathol 1, Sch Med, Mizuho Ku, Nagoya, Aichi 4678601, Japan
[2] LycoRed Nat Prod Ind Ltd, IL-84102 Beer Sheva, Israel
[3] Lion Corp, Edogawa Ku, Tokyo 1320035, Japan
[4] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 6028566, Japan
关键词
D O I
10.1093/carcin/22.3.467
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The chemopreventive efficacy of lycopene and curcumin with regard to prostate carcinogenesis was investigated using 3,2'-dimethyl-4-aminobiphenol (DMAB)- and 2-amino-1-methylimidazo[4,5-b]pyridine (PhIP)-induced rat ventral prostate cancer models. Three 60 week experiments with male F344 rats were carried out, In the first DMAB was given for the first 20 weeks and lycopene or curcumin were administered concomitantly or subsequently at dietary doses of 15 and 500 p.p.m., respectively. In the second experiment lycopene and curcumin were given to rats pretreated with DMAB at doses of 5, 15 or 45 p.p.m. or 100 or 500 p.p.m. In the third PhIP was selected as an initiator for prostate carcinogenesis and administered for 20 weeks, Rats were then fed a diet containing lycopene at a dose of 45 p.p.m. or curcumin at a dose of 500 p.p.m. or both together, Chemopreventive effects of lycopene and curcumin on development of DMAB-induced ventral prostate carcinomas were observed only in the first experiment and no confirmation of inhibition potential was obtained in the following studies. Neither summational nor synergistic chemoprevention was evident. It is concluded from the present data that, overall, neither lycopene nor curcumin can consistently prevent rat prostate carcinogenesis.
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页码:467 / 472
页数:6
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