Alcohol-induced oxidative stress

被引：479

作者：

Das, Subir Kumar ^{[1
]}

Vasudevan, D. M. ^{[1
]}

机构：

[1] Amrita Inst Med Sci, Dept Biochem, Cochin 682026, Kerala, India

来源：

LIFE SCIENCES | 2007年 / 81卷 / 03期

关键词：

alcohol; ethanol; glutathione; hydroxy ethyl radical; Kupffer cells; NF-kappa B; mitochondria; oxidative stress; reactive oxygen species; reactive nitrogen species signal transduction; tumor necrosis factor-alpha;

D O I：

10.1016/j.lfs.2007.05.005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). These form an environment favourable to oxidative stress. Ethanol treatment results in the depletion of GSH levels and decreases antioxidant activity. It elevates malondialdehyde (MDA), hydroxyethyl radical (HER), and hydroxynonenal (HNE) protein adducts. These cause the modification of all biological structures and consequently result in serious malfunction of cells and tissues. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：177 / 187

页数：11

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