First crystallographic signature of an acyclic peptide nanorod: molecular mechanism of nanorod formation by a self-assembled tetrapeptide

被引:35
作者
Haldar, D
Banerjee, A [1 ]
Drew, MGB
Das, AK
Banerjee, A [1 ]
机构
[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India
[2] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England
关键词
D O I
10.1039/b302472p
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A terminally protected acyclic tetrapeptide Boc-Aib-Val-Aib-beta-Ala-OMe 1 (Aib: alpha-aminoisobutyric acid, beta-Ala: beta-Alanine) self-assembles into a continuous hydrogen-bonded supramolecular helix with an average diameter of 10Angstrom (1nm) starting from a double bend molecular conformation in crystals and further self-assembly of this supramolecular architecture leads to the formation of polydisperse nanorods of diameters 10-40 nm.
引用
收藏
页码:1406 / 1407
页数:2
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