Lysophosphatidic acid receptors

被引：356

作者：

Contos, JJA ^{[1
]}

Ishii, I ^{[1
]}

Chun, J ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, Program Neurosci, La Jolla, CA 92093 USA

来源：

MOLECULAR PHARMACOLOGY | 2000年 / 58卷 / 06期

关键词：

D O I：

10.1124/mol.58.6.1188

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, lp(A1)/ vzg-1/Edg2, lp(A2)/Edg4, and lp(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

引用

页码：1188 / 1196

页数：9

共 57 条

[1]

Allard J, 1999, GLIA, V26, P176, DOI 10.1002/(SICI)1098-1136(199904)26:2<176::AID-GLIA8>3.0.CO

[2]

2-K

[3] A rat G protein-coupled receptor selectively expressed in myelin-forming cells [J].

Allard, J ;

Barrón, S ;

Diaz, J ;

Lubetzki, C ;

Zalc, B ;

Schwartz, JC ;

Sokoloff, P .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (03) :1045-1053

[4] Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids [J].

An, SZ ;

Bleu, T ;

Huang, W ;

Hallmark, OG ;

Coughlin, SR ;

Goetzl, EJ .

FEBS LETTERS, 1997, 417 (03) :279-282

[5] Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization [J].

An, SZ ;

Bleu, T ;

Zheng, YH ;

Goetzl, EJ .

MOLECULAR PHARMACOLOGY, 1998, 54 (05) :881-888

[6] Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid [J].

An, SZ ;

Bleu, T ;

Hallmark, OG ;

Goetzl, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :7906-7910

[7] Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid [J].

An, SZ ;

Dickens, MA ;

Bleu, T ;

Hallmark, OG ;

Goetzl, EJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 231 (03) :619-622

[8] Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid [J].

Bandoh, K ;

Aoki, J ;

Hosono, H ;

Kobayashi, S ;

Kobayashi, T ;

Murakami-Murofushi, K ;

Tsujimoto, M ;

Arai, H ;

Inoue, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27776-27785

[9] G-ALPHA(12) AND G-ALPHA(13) STIMULATE RHO-DEPENDENT STRESS FIBER FORMATION AND FOCAL ADHESION ASSEMBLY [J].

BUHL, AM ;

JOHNSON, NL ;

DHANASEKARAN, N ;

JOHNSON, GL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (42) :24631-24634

[10] Lysophospholipid receptors: Implications for neural signaling [J].

Chun, J .

CRITICAL REVIEWS IN NEUROBIOLOGY, 1999, 13 (02) :151-168

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