Changes in dendritic structure and function following hippocampal lesions: Correlations with developmental events?

被引：14

作者：

Bulinski, JC

Ohm, T

Roder, H

Spruston, N

Turner, DA

Wheal, HV

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA

[3] Univ Klinikum Charite Berlin, Inst Anat, D-10098 Berlin, Germany

[4] Bayer Corp, Inst Dementia Res, West Haven, CT 06516 USA

[5] Northwestern Univ, Inst Neurosci, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[6] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

[7] Univ Southampton, Neurosci Res Grp, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

PROGRESS IN NEUROBIOLOGY | 1998年 / 55卷 / 06期

关键词：

D O I：

10.1016/S0301-0082(98)00023-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recovery after nervous system lesions may lead to partial re-institution of developmental schemes and processes. Here we review several of these proposed schemes, with the conclusion that though some processes may involve re-expression of embryonic phenotypes, there are many processes invoked during recovery from lesions that do not mirror developmental phenomena. The inability to fully revert to embryonic schemes because of adult phenotype may partially account for the decreased recovery observed in adults compared to that noted after lesions during development. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：641 / 650

页数：10

共 93 条

[1] STRUCTURE AND PLASTICITY OF NEWLY FORMED ADULT SYNAPSES - A MORPHOMETRIC STUDY IN THE RAT HIPPOCAMPUS [J].