Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports

被引：31

作者：

Brickell, K ^{[1
]}

Porter, D ^{[1
]}

Thompson, P ^{[1
]}

机构：

[1] Auckland Hosp, Dept Oncol, Auckland 1, New Zealand

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 04期

关键词：

phenytoin; fluoropyrimidine; fluorouracil; capecitabine;

D O I：

10.1038/sj.bjc.6601137

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbidities are now being considered for chemotherapy, it is increasingly likely that people receiving phenytoin will be prescribed treatment with fluoropyrimidines. We present two cases of clinical phenytoin toxicity occurring after starting treatment with 5-fluorouracil/folinic acid (5FU/FA) and a third who developed clinical phenytoin toxicity after starting capecitabine ( an orally administered prodrug of fluorouracil).

引用

页码：615 / 616

页数：2

共 10 条

[1] Severe phenytoin intoxication in a subject homozygous for CYP2C9*3 [J].