Activity of telithromycin compared with seven other agents against 1039 Streptococcus pyogenes pediatric isolates from ten centers in central and eastern Europe

被引：17

作者：

Bozdogan, B

Appelbaum, PC

Kelly, LM

Hoellman, DB

Tambic-Andrasevic, A

Drukalska, L

Hryniewicz, W

Hupkova, H

Jacobs, MR

Kolman, J

Konkoly-Thege, M

Miciuleviciene, J

Pana, M

Setchanova, L

Trupl, J

Urbaskova, P

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

[2] Univ Zagreb, Univ Hosp Infect Dis, Zagreb, Croatia

[3] Med Acad Latvia, Childrens Hosp, Riga, Latvia

[4] Sera & Vaccine Lab, Warsaw, Poland

[5] St Cyril & Method Hosp, Bratislava, Slovakia

[6] Case Western Reserve Univ, Cleveland, OH 44106 USA

[7] Univ Ljubljana, Ljubljana, Slovenia

[8] Natl Ctr Epidemiol, Budapest, Hungary

[9] Kaunas Med Univ Hosp, Kaunas, Lithuania

[10] Inst Cantacuzino, Bucharest, Romania

[11] Acad Med Sofia, Hosp Infect Dis, Sofia, Bulgaria

[12] Natl Canc Inst, Bratislava, Slovakia

[13] Natl Antibiot Reference Lab, Prague, Czech Republic

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2003年 / 9卷 / 07期

关键词：

telithromycin; Streptococcus pyogenes; macrolide resistance;

D O I：

10.1046/j.1469-0691.2003.00598.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In total, 1039 pediatric Streptococcus pyogenes isolates from Bulgaria, Croatia, the Czech Republic, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia and Slovenia were studied. All strains were susceptible to penicillin G, levofloxacin, and quinupristin-dalfopristin, 91-100% to telithromycin, and 82-100% to erythromycin, azithromycin, and clarithromycin, and 90-100% to clindamycin. Macrolide resistance occurred mainly in Slovakia (25%), the Czech Republic (17.3%), and Croatia (15.8%). Overall, 9.7% of S. pyogenes isolates were erythromycin resistant due to erm(B) - or erm(A) -encoded methylases (72.3%) or to a mef(A) -encoded efflux pump (25.7%). One strain had alterations of both 23S rRNA (A2058G Escherichia coli numbering) and ribosomal protein L22 (G95D).

引用

页码：741 / 745

页数：5

共 19 条

[1] High prevalence of erythromycin-resistant, clindamycin/miocamycin-susceptible (M phenotype) Streptococcus pyogenes:: results of a Spanish multicentre study in 1998 [J].