Genome scan for determinants of serum uric acid variability

被引：74

作者：

Nath, Subrata D. ^{[1
]}

Voruganti, Saroja ^{[2
]}

Arar, Nedal H. ^{[1
]}

Thameem, Farook ^{[1
]}

Lopez-Alvarenga, Juan C. ^{[2
]}

Bauer, Richard ^{[1
]}

Blangero, John ^{[2
]}

MacCluer, Jean W. ^{[2
]}

Comuzzie, Anthony G. ^{[2
]}

Abboud, Hanna E. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Nephrol, San Antonio, TX 78229 USA

[2] SW Fdn Biomed Res, Dept Genet, San Antonio, TX USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2007年 / 18卷 / 12期

关键词：

D O I：

10.1681/ASN.2007040426

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated serum uric acid level is associated with obesity, insulin resistance, diabetes, nephropathy, and hypertension. Epidemiologic studies suggest that serum uric acid levels are heritable. We sought to identify chromosomal regions harboring quantitative trait loci that influence serum uric acid in Mexican Americans using data from 644 participants in the San Antonio Family Heart Study. Serum uric acid was found to exhibit significant heritability (0.42) in this population (P = 2 X 10(-7)) after accounting for covariate effects. In addition, genetic correlations between serum uric acid and other cardiovascular risk factors, such as body mass index, waist circumference, systolic BP, and pulse pressure, were identified, suggesting that the genes associated with uric acid level are also associated with these phenotypes. Multipoint linkage analysis identified quantitative trait loci with measurable effects on serum uric acid variability. The highest multipoint logarithm of odds score of 3.3 was found at 133 cM on chromosome 6q22-23, a region that also contains genes that seem to influence familial IgA nephropathy, obesity, BP, insulin resistance, and type 2 diabetes. Given the relationship between uric acid level and these conditions, future studies should investigate potential candidate susceptibility genes found in this region.

引用

页码：3156 / 3163

页数：8

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