Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease

被引：96

作者：

Davidsson, P ^{[1
]}

Blennow, K

Andreasen, N

Eriksson, B

Minthon, L

Hesse, C

机构：

[1] Sahlgrens Univ Hosp, Univ Gothenburg, Dept Clin Neurosci, Expt Neurosci Sect, S-43180 Molndal, Sweden

[2] Pitea River Valley Hosp, Dept Rehabil, Pitea, Sweden

[3] Janssen Cilag AB, Vastra Frolunda, Sweden

[4] Lund Univ, Malmo Univ Hosp, Dept Community Med, Neuropsychiat Clin, Malmo, Sweden

来源：

NEUROSCIENCE LETTERS | 2001年 / 300卷 / 03期

关键词：

acetylcholinesterase; cerebrospinal fluid; Alzheimer's disease; acetylcholine esterase inhibitors;

D O I：

10.1016/S0304-3940(01)01586-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The clinical significance and the effects of pharmacological treatment of patients with Alzheimer's disease (AD) were evaluated by measurement of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF). CSF-AChE of AD patients was lower, not significantly, compared with controls. However, CSF-AChE was significantly increased after treatment of AD patients with AChE inhibitors (donepezil and galantamine). The increase was higher in patients treated with donezepil than in those treated with galantamine, which might be related to different mechanisms for the substances. The increase was also dose-dependent, and was especially marked in patients showing a clinical response. These data suggest that CSF biomarkers are capable not only of identifying a biochemical effect of drugs, but also of differentiating between different compounds in a dose-dependent manner. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：157 / 160

页数：4

共 17 条

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[2]

[Anonymous], 2000, Cholinesterases and cholinesterase inhibitors

[3] CHOLINESTERASE ACTIVITIES IN CEREBROSPINAL-FLUID OF PATIENTS WITH SENILE DEMENTIA OF ALZHEIMER TYPE [J].