Apoptotic and anti-angiogenic strategies in liver and gastrointestinal malignancies

被引：70

作者：

Kountouras, J ^{[1
]}

Zavos, C ^{[1
]}

Chatzopoulos, D ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Ippokrat Hosp, Med Clin 2, Dept Med, GR-54006 Thessaloniki, Greece

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2005年 / 90卷 / 04期

关键词：

apoptosis; angiogenesis; cancer; tumorigenesis; vascular endothelial growth factor;

D O I：

10.1002/jso.20254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Inappropriate suppression of apoptosis is strongly implicated in tumorigenesis. Tumor development is heralded by the mutation of tumor suppressor genes and overexpression of anti-apoptotic genes permitting cell survival. Thus, inducing the apoptotic process in various ways can be applied to cancer management. Besides, angiogenesis is a crucial process for tumor growth and metastasis. New strategies targeting fundamental play-markers of the angiogenic process are currently under investigation. (c) 2005 Wiley-Liss, Inc.

引用

页码：249 / 259

页数：11

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