Progress in the development of respiratory syncytial virus and parainfluenza virus vaccines

被引：64

作者：

Durbin, AP

Karron, RA

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, Baltimore, MD 21205 USA

[2] Johns Hopkins Sch Med, Dept Med, Baltimore, MD USA

[3] Johns Hopkins Sch Med, Dept Pediat, Baltimore, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 37卷 / 12期

关键词：

D O I：

10.1086/379775

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Respiratory syncytial virus ( RSV) and human parainfluenza viruses ( hPIVs) are leading causes of viral lower respiratory tract illness in children and in high- risk adult populations. Despite decades of research, licensed vaccines for RSV and hPIVs do not exist. Recently, however, genetically engineered live attenuated RSV and hPIV candidate vaccines have been generated, several of which are already being evaluated in clinical trials. Recombinant technology allows candidate vaccines to be " fine-tuned" in response to clinical data, which should hasten the development of vaccines against these important respiratory pathogens.

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收藏

页码：1668 / 1677

页数：10

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