Photoreactions of N-alkoxy-4-(p-chlorophenyl)thiazole-2(3H)-thiones with L-cysteine derivatives in aqueous solutions

被引：11

作者：

Hartung, J ^{[1
]}

Kneuer, R ^{[1
]}

Spehar, K ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 09期

关键词：

D O I：

10.1039/b101097m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photolysis of substituted N-alkoxythiazolethiones 1 in aqueous solvents furnishes alkoxyl radicals 2 which, upon stereoselective 5-exo-trig cyclization, are trapped by water soluble thiols (l-cysteine, l-cysteine ethyl ester, or the reduced form of glutathione, GSH) to afford disubstituted tetrahydrofurans 3 in synthetically useful yields and with satisfactory to excellent diastereoselectivities.

引用

页码：799 / 800

页数：2

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