Genetics of multiple myeloma: another heterogeneity level?

被引：114

作者：

Corre, Jill ^{[1
,2
]}

Munshi, Nikhil ^{[3
,4
]}

Avet-Loiseau, Herve ^{[1
,2
]}

机构：

[1] CHU, IUCT Oncopole, Unit Genom Myeloma, F-31059 Toulouse, France

[2] Inst Natl Sante & Rech Med, Ctr Rech Cancerol Toulouse, U1037, Toulouse, France

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA

[4] Boston Vet Adm Healthcare Syst, West Roxbury, MA USA

来源：

BLOOD | 2015年 / 125卷 / 12期

基金：

美国国家卫生研究院;

关键词：

PLASMA-CELL LEUKEMIA; ADVERSE PROGNOSTIC-FACTOR; IN-SITU HYBRIDIZATION; MONOCLONAL GAMMOPATHY; UNDETERMINED SIGNIFICANCE; MOLECULAR CLASSIFICATION; INTERGROUPE FRANCOPHONE; C-MAF; EXPRESSION; TRANSLOCATIONS;

D O I：

10.1182/blood-2014-10-567370

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Our knowledge of myeloma genetics remained limited and lagged behind many other hematologic malignancies because of the inherent difficulties in generating metaphases within the malignant plasma cell clone. With the development of molecular techniques (microarrays and next-generation sequencing), our understanding has been highly improved in the past 5 years. These studies have not only confirmed the prevalence of wide heterogeneity in myeloma at the molecular level, but has also provided a much clearer picture of the disease pathogenesis and progression. Whether these data will enable improvements in the therapeutic approach is still a matter of debate. The next improvement will come from detailed analyses of these molecular features to try to move from a treatment fitted to every patient to individualized therapies, taking into account the complexity of the chromosomal changes, the mutation spectrum, and subclonality evolution.

引用

页码：1870 / 1876

页数：7

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