Histamine Stimulates Neurogenesis in the Rodent Subventricular Zone

被引：36

作者：

Bernardino, Liliana ^{[1
,2
,3
]}

Eiriz, Maria Francisca ^{[2
]}

Santos, Tiago ^{[2
]}

Xapelli, Sara ^{[2
]}

Grade, Sofia ^{[2
]}

Rosa, Alexandra Isabel ^{[2
]}

Cortes, Luisa ^{[2
]}

Ferreira, Raquel ^{[2
]}

Braganca, Jose ^{[4
]}

Agasse, Fabienne ^{[2
]}

Ferreira, Lino ^{[2
]}

Malva, Joao O. ^{[1
,2
]}

机构：

[1] Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal

[2] Univ Beira Interior, Ctr Neurosci & Cell Biol, Covilha, Portugal

[3] Univ Beira Interior, Hlth Sci Res Ctr, Covilha, Portugal

[4] Univ Algarve, Inst Biotechnol & Bioengn, Ctr Mol & Struct Biomed, Faro, Portugal

来源：

STEM CELLS | 2012年 / 30卷 / 04期

关键词：

Subventricular zone; Histamine; Biocompatible microparticles; Neuronal differentiation; EMBRYONIC STEM-CELLS; NECROSIS-FACTOR-ALPHA; NEURONAL DIFFERENTIATION; CSF HISTAMINE; PRECOLUMN DERIVATIZATION; PROMOTES NEUROGENESIS; TELE-METHYLHISTAMINE; CEREBROSPINAL-FLUID; PROGENITOR CELLS; BRAIN;

D O I：

10.1002/stem.1042

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Neural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. STEM CELLS 2012; 30:773784

引用

页码：773 / 784

页数：12

共 52 条

[1]

Neuropeptide Y promotes neurogenesis in murine subventricular zone [J].

Agasse, Fabienne ;

Bernardino, Liliana ;

Kristiansen, Heidi ;

Christiansen, Soren H. ;

Ferreira, Raquel ;

Silva, Bruno ;

Grade, Sofia ;

Woldbye, David P. D. ;

Malva, Joao O. .

STEM CELLS, 2008, 26 (06) :1636-1645

[2]

Response to histamine allows the functional identification of neuronal progenitors, neurons, astrocytes, and immature cells in subventricular zone cell cultures [J].

Agasse, Fabienne ;

Bernardino, Liliana ;

Silva, Bruno ;

Ferreira, Raquel ;

Grade, Sofia ;

Malva, Joao O. .

REJUVENATION RESEARCH, 2008, 11 (01) :187-200

[3]

Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease [J].

Alvarez, XA ;

Franco, A ;

FernandezNovoa, L ;

Cacabelos, R .

MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1996, 29 (2-3) :237-252

[4]

Inhibited neurogenesis in JNK1-deficient embryonic stem cells [J].

Amura, CR ;

Marek, L ;

Winn, RA ;

Heasley, LE .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (24) :10791-10802

[5]

An altered histaminergic innervation of the substantia nigra in Parkinson's disease [J].

Anichtchik, OV ;

Rinne, JO ;

Kalimo, H ;

Panula, P .

EXPERIMENTAL NEUROLOGY, 2000, 163 (01) :20-30

[6]

Modulator effects of interleukin-1β and tumor necrosis factor-α on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures [J].

Bernardino, L ;

Xapelli, S ;

Silva, AP ;

Jakobsen, B ;

Poulsen, FR ;

Oliveira, CR ;

Vezzani, A ;

Malva, JO ;

Zimmer, J .

JOURNAL OF NEUROSCIENCE, 2005, 25 (29) :6734-6744

[7]

Tumor necrosis factor-α modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures [J].

Bernardino, Liliana ;

Agasse, Fabienne ;

Silva, Bruno ;

Ferreira, Raquel ;

Grade, Sofia ;

Malva, Joao O. .

STEM CELLS, 2008, 26 (09) :2361-2371

[8]

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases [J].

Bogoyevitch, Marie A. ;

Kobe, Bostjan .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2006, 70 (04) :1061-+

[9]

Simultaneous quantitation of histamine and its major metabolite 1-methylhistamine in brain dialysates by using precolumn derivatization prior to HILIC-MS/MS analysis [J].

Bourgogne, E. ;

Mathy, F-X. ;

Boucaut, D. ;

Boekens, H. ;

Laprevote, O. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 402 (01) :449-459

[10]

The physiology of brain histamine [J].

Brown, RE ;

Stevens, DR ;

Haas, HL .

PROGRESS IN NEUROBIOLOGY, 2001, 63 (06) :637-672

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