Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents

被引：45

作者：

Kabalka, GW ^{[1
]}

Das, BC

Das, S

机构：

[1] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA

[2] Univ Tennessee, Dept Radiol, Knoxville, TN 37996 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(01)01486-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two boronated alpha -amino acids, 1-amino-3-boronocyclopentanecarboxylic acid and 1-amino-3-boronocycloheptanecarboxylic acid were prepared. The key step in the syntheses was the 1,4-boration of the alpha,beta -unsaturated cyclic ketones using the bis-pinacolatodiboron ester to generate the boronated ketones which were then converted to the corresponding amino acids. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：7145 / 7146

页数：2

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