Platelet-rich plasma - Growth factor enhancement for bone grafts

被引:1891
作者
Marx, RE [1 ]
Carlson, ER [1 ]
Eichstaedt, RM [1 ]
Schimmele, SR [1 ]
Strauss, JE [1 ]
Georgeff, KR [1 ]
机构
[1] Univ Miami, Sch Med, Div Oral & Maxillofacial Surg, Coral Gables, FL 33146 USA
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 1998年 / 85卷 / 06期
关键词
D O I
10.1016/S1079-2104(98)90029-4
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Platelet-rich plasma is an autologous source of platelet-derived growth factor and transforming growth factor beta that is obtained by sequestering and concentrating platelets by gradient density centrifugation. This technique produced a concentration of human platelets of 338% and identified platelet-derived growth factor and transforming growth factor beta within them. Monoclonal antibody assessment of cancellous cellular marrow grafts demonstrated cells that were capable of responding to the growth factors by bearing cell membrane receptors. The additional amounts of these growth factors obtained by adding platelet-rich plasma to grafts evidenced a radiographic maturation rate 1.62 to 2.16 times that of grafts without platelet-rich plasma. As assessed by histomorphometry, there was also a greater bone density in grafts in which platelet-rich plasma was added (74.0% +/- 11%)than in grafts in which platelet-rich plasma was not added (55.1% +/- 8%; p = 0.005).
引用
收藏
页码:638 / 646
页数:9
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