Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

被引：390

作者：

Sasaki, E

Kojima, H

Nishimatsu, H

Urano, Y

Kikuchi, K

Hirata, Y

Nagano, T

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan

[3] Japan Sci & Technol Corp, PRESTO, Kawaguchi, Saitama, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 11期

关键词：

D O I：

10.1021/ja042967z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging. Copyright © 2005 American Chemical Society.

引用

页码：3684 / 3685

页数：2

共 11 条

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