Interaction of viruses with host cell molecular motors

被引：26

作者：

Hsieh, Ming Je ^{[1
]}

White, Paul J. ^{[1
]}

Pouton, Colin W. ^{[1
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Melbourne, Vic 3004, Australia

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2010年 / 21卷 / 05期

关键词：

NUCLEAR-PORE COMPLEX; CYTOPLASMIC DYNEIN; VACCINIA VIRUS; ADENOVIRUS; PROTEIN; MICROTUBULE; TRANSPORT; ENTRY; DNA; VISUALIZATION;

D O I：

10.1016/j.copbio.2010.06.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral particles are generally too large to diffuse freely within the crowded environment of the host cell cytoplasm. They depend on mammalian cell transport systems, in particular the microtubular molecular motor dynein, to deliver their nucleic acids to the vicinity of the nucleus. An understanding of how viruses interact with dynein, and its many accessory proteins, may reveal targets for drug discovery and will unlock the toolbox required to improve the performance of synthetic gene delivery systems.

引用

页码：633 / 639

页数：7

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