Recent insights into angiogenesis, apoptosis, invasion, and metastasis in colorectal carcinoma

被引：40

作者：

Boedefeld, WM ^{[1
]}

Bland, KI ^{[1
]}

Heslin, MJ ^{[1
]}

机构：

[1] Univ Alabama, Dept Surg, Birmingham, AL 35243 USA

来源：

ANNALS OF SURGICAL ONCOLOGY | 2003年 / 10卷 / 08期

关键词：

angiogenesis; apoptosis; invasion; colorectal carcinoma;

D O I：

10.1245/ASO.2003.02.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The numerous studies profiling mechanisms in colorectal carcinoma have implicated multiple pathways in the malignant progression of a colorectal epithelial cell. Such pathways as aberrations in the cell cycle, deviation from apoptosis, neovascularization of tumors, and invasion and metastasis of malignant epithelial cells have been shown to occur in the progression of a normal epithelial cell to an adenoma and carcinoma. Today, we continue to search for communications or connections between these pathways as we try to get a more global picture of the events responsible for the adenoma-carcinoma sequence. This review focuses on the latest developments of three well-characterized pathways implicated in colorectal carcinoma: angiogenesis, apoptosis, and invasion and metastasis. We will attempt to highlight clinical correlates, when available, with some of the more interesting molecules.

引用

页码：839 / 851

页数：13

共 124 条

[1] Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) [J].