Honokiol induces apoptosis in human lymphoid leukemia Molt 4B cells

被引：10

作者：

Hibasami, H

Achiwa, Y

Katsuzaki, H

Imai, K

Yoshioka, K

Nakanishi, K

Ishii, Y

Hasegawa, M

Komiya, T ^{[1
]}

机构：

[1] Mie Univ, Fac Bioresources, Tsu, Mie 5148507, Japan

[2] Mie Univ, Fac Med, Tsu, Mie 5148507, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 1998年 / 2卷 / 06期

关键词：

honokiol; growth inhibition; apoptosis; DNA fragmentation; human lymphoid leukemia;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The exposure of human lymphoid leukemia Molt 4B cells to honokiol led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with honokiol. The fragmentation by honokiol of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition by honokiol of Molt 4B cells results from the induction of apoptosis in the cells.

引用

页码：671 / 673

页数：3

共 17 条

[1] THE INDUCTION OF APOPTOSIS IS A COMMON FEATURE OF THE CYTOTOXIC ACTION OF ETHER-LINKED GYLCEROPHOSPHOLIPIDS IN HUMAN LEUKEMIC-CELLS [J].