TGF-β, neuronal stem cells and glioblastoma

被引:71
作者
Golestaneh, N [1 ]
Mishra, B [1 ]
机构
[1] Georgetown Univ, Sch Med, Dev Neurobiol Lab, Washington, DC 20007 USA
关键词
TGF-beta; CNS cancer; glioblastoma; ELF; Smad;
D O I
10.1038/sj.onc.1208925
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transforming growth factor beta (TGF-beta) signaling leads to a number of biological end points involving cell growth, differentiation, and morphogenesis. Typically, the cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell differentiation. However, during pathological conditions, these defined effects of TGF-beta can be reversed; for example, the growth-inhibitory effect is replaced with its tumor promoting ability. A multitude of factors and cross-signaling pathways have been reported to be involved in modulating the dual effects of TGF-beta. In this review, we focus on the potential role of TGF-beta signal transduction during development of neural progenitor cells and its relation to glioblastoma development from neural stem cells.
引用
收藏
页码:5722 / 5730
页数:9
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