Infection of the skin caused by Corynebacterium ulcerans and mimicking classical cutaneous diphtheria

被引:30
作者
Wagner, J
Ignatius, R
Voss, S
Höpfner, V
Ehlers, S
Funke, G
Weber, U
Hahn, H
机构
[1] Free Univ Berlin, Benjamin Franklin Med Ctr, Dept Med Microbiol & Immunol Infect, D-12203 Berlin, Germany
[2] Free Univ Berlin, Benjamin Franklin Med Ctr, Orthoped Clin, D-12203 Berlin, Germany
[3] Unfallbehandlungsstelle Berufsgenossensch Berlin, Berlin, Germany
[4] Gartner & Colleagues Labs, Dept Med Microbiol, Weingarten, Germany
关键词
D O I
10.1086/322969
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Extrapharyngeal infections caused by Corynebacterium ulcerans have rarely been reported previously, and diphtheria toxin production has usually not been addressed. This case demonstrates that strains of C. ulcerans that produce diphtheria toxin can cause infections of the skin that completely mimic typical cutaneous diphtheria, thereby potentially providing a source of bacteria capable of causing life-threatening diseases in the patient's environment. Therefore, it is recommended to screen wound swabs for coryneform bacteria, identify all isolates, carefully assess possible toxin production, and send questionable strains to a specialist or a reference laboratory.
引用
收藏
页码:1598 / 1600
页数:3
相关论文
共 20 条
[1]  
Bonnet J M, 1999, Commun Dis Public Health, V2, P242
[2]  
Brown AE, 2000, PRINCIPLES PRACTICE, P2198
[3]   THE EXOTOXINS OF CORYNEBACTERIUM-ULCERANS [J].
CARNE, HR ;
ONON, EO .
JOURNAL OF HYGIENE, 1982, 88 (02) :173-191
[4]  
*CDC, 1997, MMWR-MORBID MORTAL W, V46, P330
[5]  
Efstratiou A, 1999, Commun Dis Public Health, V2, P250
[6]   Comparison of phenotypic and genotypic methods for detection of diphtheria toxin among isolates of pathogenic corynebacteria [J].
Efstratiou, A ;
Engler, KH ;
Dawes, CS ;
Sesardic, D .
JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (11) :3173-3177
[7]   A modified Elek test for detection of toxigenic corynebacteria in the diagnostic laboratory [J].
Engler, KH ;
Glushkevich, T ;
Mazurova, IK ;
George, RC ;
Efstratiou, A .
JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (02) :495-498
[8]   Multicenter evaluation of the updated and extended API (RAPID) Coryne database 2.0 [J].
Funke, G ;
Renaud, FNR ;
Freney, J ;
Riegel, P .
JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (12) :3122-3126
[9]   Clinical microbiology of coryneform bacteria [J].
Funke, G ;
vonGraevenitz, A ;
Clarridge, JE ;
Bernard, KA .
CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (01) :125-+
[10]   DIPHTHERIA - CHANGING PATTERNS IN THE DEVELOPING-WORLD AND THE INDUSTRIALIZED WORLD [J].
GALAZKA, AM ;
ROBERTSON, SE .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1995, 11 (01) :107-117