Coronary artery diameter increase induced by a phosphodiesterase 5 inhibitor, E4021, in conscious pigs

被引：11

作者：

Adachi, H ^{[1
]}

Nishino, M ^{[1
]}

机构：

[1] Eisai & Co Ltd, Tsukuba Res Labs, Cardiovasc Res Unit, Tsukuba, Ibaraki 3002635, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 77卷 / 01期

关键词：

phosphodiesterase; 5; inhibitor; coronary diameter; conscious pig;

D O I：

10.1254/jjp.77.99

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of intravenous infusions of 1, 3 and 10 mu g/kg/min of the phosphodiesterase 5 inhibitor, E4021, at 30-min intervals on coronary artery diameter were studied in 8 conscious pigs monitored with a pair of piezoelectric crystals. The highest dose increased the diameter by 2.9 +/- 0.5% (P < 0.01 vs vehicle) of the baseline diameter, with a significant decrease in mean pulmonary arterial pressure. However, there were no changes in mean aortic pressure and heart rate. Additionally, E4021 significantly prolonged the duration of the diameter increase induced by nitroglycerin. Thus, phosphodiesterase 5 inhibition causes coronary artery diameter increase and produces an amplifying effect with nitroglycerin.

引用

页码：99 / 102

页数：4

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