Coronary artery diameter increase induced by a phosphodiesterase 5 inhibitor, E4021, in conscious pigs

被引:11
作者
Adachi, H [1 ]
Nishino, M [1 ]
机构
[1] Eisai & Co Ltd, Tsukuba Res Labs, Cardiovasc Res Unit, Tsukuba, Ibaraki 3002635, Japan
关键词
phosphodiesterase; 5; inhibitor; coronary diameter; conscious pig;
D O I
10.1254/jjp.77.99
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of intravenous infusions of 1, 3 and 10 mu g/kg/min of the phosphodiesterase 5 inhibitor, E4021, at 30-min intervals on coronary artery diameter were studied in 8 conscious pigs monitored with a pair of piezoelectric crystals. The highest dose increased the diameter by 2.9 +/- 0.5% (P < 0.01 vs vehicle) of the baseline diameter, with a significant decrease in mean pulmonary arterial pressure. However, there were no changes in mean aortic pressure and heart rate. Additionally, E4021 significantly prolonged the duration of the diameter increase induced by nitroglycerin. Thus, phosphodiesterase 5 inhibition causes coronary artery diameter increase and produces an amplifying effect with nitroglycerin.
引用
收藏
页码:99 / 102
页数:4
相关论文
共 15 条
[1]  
ADACHI H, 1987, J PHARMACOL EXP THER, V241, P1072
[2]  
ADACHI H, 1989, EUR J PHARMACOL, V161, P189
[3]  
ADACHI H, 1994, J PHARMACOL EXP THER, V268, P133
[4]  
BEAVO JA, 1994, MOL PHARMACOL, V46, P399
[5]  
Boolell M, 1996, Int J Impot Res, V8, P47
[6]   PULMONARY VASODILATOR RESPONSES TO ATRIAL NATRIURETIC FACTOR AND SODIUM-NITROPRUSSIDE [J].
CIGARINI, I ;
ADNOT, S ;
CHABRIER, PE ;
VIOSSAT, I ;
BRAQUET, P ;
GAUJOUR, B .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (06) :2269-2275
[7]   CHARACTERIZATION OF A NOVEL POTENT AND SPECIFIC INHIBITOR OF TYPE-V PHOSPHODIESTERASE [J].
COSTE, H ;
GRONDIN, P .
BIOCHEMICAL PHARMACOLOGY, 1995, 50 (10) :1577-1585
[8]   Cardiovascular effects of a novel, potent and selective phosphodiesterase 5 inhibitor, DMPPO: In vitro and in vivo characterization [J].
Delpy, E ;
deGouville, ACL .
BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (06) :1377-1384
[9]  
DINHXUAN AT, 1993, CIRCULATION, V87, P81
[10]   REACTIVE DILATION OF LARGE CORONARY-ARTERIES IN CONSCIOUS DOGS [J].
HINTZE, TH ;
VATNER, SF .
CIRCULATION RESEARCH, 1984, 54 (01) :50-57