Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

被引：222

作者：

Deupi, Xavier ^{[1
]}

Kobilka, Brian K. ^{[2
]}

机构：

[1] Univ Autonoma Barcelona, Fac Med, Unitat Bioestadist, Catalunya, Spain

[2] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA

来源：

PHYSIOLOGY | 2010年 / 25卷 / 05期

关键词：

PROTEIN-COUPLED-RECEPTORS; BETA(2) ADRENERGIC-RECEPTOR; BETA(2)-ADRENERGIC RECEPTOR; RHODOPSIN ACTIVATION; CRYSTAL-STRUCTURE; 7-TRANSMEMBRANE RECEPTORS; CONFORMATIONAL-CHANGES; IONIC LOCK; REVEALS; SWITCHES;

D O I：

10.1152/physiol.00002.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.

引用

页码：293 / 303

页数：11

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