Presynaptic effects of octopamine, serotonin, and cocktails of the two modulators on neuromuscular transmission in crustaceans

被引:33
作者
Djokaj, S [1 ]
Cooper, RL
Rathmayer, W
机构
[1] Univ Konstanz, Dept Biol, D-78457 Constance, Germany
[2] Univ Kentucky, Thomas Hunt Morgan Sch Biol Sci, Lexington, KY 40506 USA
来源
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY | 2001年 / 187卷 / 02期
基金
美国国家科学基金会;
关键词
crayfish; crab; transmitter release; biogenic amine; modulation;
D O I
10.1007/s003590100187
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effect of the biogenic amines octopamine and serotonin, and of both amines combined (cocktails) on transmitter release at neuromuscular junctions of two crustaceans was studied. octopamine (10(-8) mol l(-1) to 10(-6) mol l(-1)) either enhanced or decreased evoked transmitter release through presynaptic effects.. The results were identical for the slow and the fast exciter in the closer muscle of the crab, and for the exciter in the opener muscle of the crayfish. Application of serotonin always resulted in a strong increase of release. However, this potentiating effect of serotonin was reduced in strength by subsequent application of cocktails consisting of serotonin and octopamine. In all experiments, a cocktail of serotonin and octopamine was less effective than serotonin alone. The decrease in the mean quantal content m by octopamine was due to a reduction of the probability of release p. Since both amines are synthesized in the central nervous system and are released from neurohaemal organs into the haemolymph bathing the neuromuscular junctions, the results suggest that the two amines, when present together, modulate transmitter release in an antagonistic way, and that the level of the two determines synaptic efficacy.
引用
收藏
页码:145 / 154
页数:10
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