Complement receptor 2 in the regulation of the immune response

被引：31

作者：

Tolnay, M

Tsokos, GC

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Clin Physiol, Washington, DC 20307 USA

[2] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1998年 / 88卷 / 02期

关键词：

complement receptor 2; B lymphocytes; immune response;

D O I：

10.1006/clin.1998.4552

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigens coated with split products of C3, the result of complement activation, are capable of crosslinking the complement receptor 2 (CR2, CD21) and the antigen receptor on the surface of B cells simultaneously. This dual recognition leads to increased cell proliferation and differentiation and enhanced antibody production. CR2 is also considered to be a regulator of the B cell response to antigen. In this review we summarize the biology of the CR2 and focus on its essential role in generating an effective B cell response to antigenic stimuli. The involvement of CR2 in the pathophysiology of infectious and autoimmune diseases is also discussed. (C) 1998 Academic Press.

引用

收藏

页码：123 / 132

页数：10

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